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Original Article

Year: 2012 | Volume: 2 | Issue 3 | Page: 123 - 133

Role of Adenosine Deaminase to Predict Glycemic Status in Type 2 Diabetes  Mellitus

Nisha Subhashchandra Ramani, Krishnamurthy N , Raghavendra Prasad B N , Ashakiran S, Sumathi M.E, Harish R

Introduction: Diabetes mellitus (DM) is a heterogeneous disease characterized by an abnormal or relative deficiency of insulin and insulin resistance. Adenosine Deaminase (ADA) is an enzyme involved in purine metabolism. Literature demonstrates that in the patients with type 2 DM, the level of ADA is higher than that of non-diabetics.
Objectives: 1. To estimate the serum ADA in patients with type 2 DM.
2. To correlate ADA levels with HbA1c (for glycemic status) in patients with type 2 DM.
Methods: The present study is a case control study. It includes 101 subjects, including 51 cases of type 2 diabetes mellitus and 50 age and sex matched healthy controls. Adenosine Deaminase, HbA1c, fasting and postprandial blood glucose levels were measured and the results were compared with controls. Results: An elevation of serum ADA was found in diabetic subjects as compared to controls. Mean and Standard deviation of serum ADA in cases and controls was 32.06 + 17.09 and 19.28+ 5.59 respectively.  Serum  ADA  is  significantly  higher  in  cases  as  compared  to  controls  (p<0.001). ADA  activity  is  correlated  with  fasting  blood  glucose  (r  =0.694,  p  <  0.001),  postprandial blood glucose (r = 0.652, p<0.001) and HbA1c (r =0.290, p<0.05). Correlation is positive and significant.
Conclusion:  Serum  ADA  is  elevated  in  the  patients  with  diabetes  as  compared  to  controls. This reflects that serum ADA can be considered as a marker of   glycemic status in the diabetic population.

Key words: Adenosine, Adenosine Deaminase, Blood glucose, HbA1c, Type 2 diabetes mellitus.
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