A Case Report of Polyostotic form of Fibrous Dysplasia: Imaging Features in Radiograph, Computed Tomography and Magnetic Resonance Imaging

nbsp         Revanth R B; Deepti Naik; Anil Kumar Sakalecha; lowast; Aashish; Yashas Ullas; Guru Yogendra M  nbsp

doi:10.58739/jcbs/v12i4.121

Article

A Case Report of Polyostotic form of Fibrous Dysplasia: Imaging Features in Radiograph, Computed Tomography and Magnetic Resonance Imaging

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Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v12i4.121

Year: 2022, Volume: 12, Issue: 4, Pages: 154-156

Case Report

A Case Report of Polyostotic form of Fibrous Dysplasia: Imaging Features in Radiograph, Computed Tomography and Magnetic Resonance Imaging

Revanth R B¹, Deepti Naik², Anil Kumar Sakalecha^3,∗, Aashish⁴, Yashas Ullas⁴, Guru Yogendra M¹

¹ Postgraduate, Department of Radio-diagnosis, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India
² Professor, Department of Radio-diagnosis, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India
³Professor & HOD, Department of Radio-diagnosis, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India
⁴Senior resident, Department of Radio-diagnosis, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India

*Corresponding author email: [email protected]

Received Date:07 October 2022, Accepted Date:30 October 2022, Published Date:22 December 2022

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Fibrous dysplasia is a disease that causes aberrant development of osteoblasts, which results in fibrous stroma replacing normal bone. Lichtenstein first described it in 1938. It is a sporadic disorder caused due to a postzygotic mutation in the GNAS1 gene. It can affect a single bone (monostotic) or several bones (polyostotic). The most common locations are the skull & ribs. It is typically an incidental finding and asymptomatic. When a pathologic fracture or malignant alteration complicates it, symptoms could develop. As polyostotic FD is a rare disorder that only occasionally occurs in 20–25% of patients, therefore the aim of this article is to report such a rare case of polyostotic FD in a 30-year-old female patient showing the characteristic changes.

Keywords: Polyostotic fibrous dysplasia, GNAS1 gene mutation, Sporadic disorder

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Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka