Adenosquamous Cell Carcinoma Secondary to Chronic Osteomyelitis of the Tibia - Rare Case Report

Anil Kumar P; Nagakumar J S; lowast

doi:10.58739/jcbs/v14i2.24.27

Article

Adenosquamous Cell Carcinoma Secondary to Chronic Osteomyelitis of the Tibia - Rare Case Report

VIEWS 2300
PDF 559

Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v14i2.24.27

Year: 2024, Volume: 14, Issue: 2, Pages: 59-61

Case Report

Adenosquamous Cell Carcinoma Secondary to Chronic Osteomyelitis of the Tibia - Rare Case Report

Anil Kumar P¹, Nagakumar J S^2,∗

¹ Assistant Professor, Department of Orthopaedics, R L Jalappa Hospital, Tamaka, Kolar, Karnataka, India
² Professor and Unit Head, Department of Orthopaedics, R L Jalappa Hospital, Tamaka, Kolar, Karnataka, India

*Corresponding author email: [email protected]

Received Date:02 April 2024, Accepted Date:07 June 2024, Published Date:24 July 2024

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Osteomyelitis is an infection with progressive destruction of bone tissue involving the bone and articular cartilage with its medullary canal. Chronic osteo-myelitis treatment is challenge for the orthopaedician. The bone microscopic anatomy and also the microorganism biofilms and their ability to adapt to their surrounding environment. It’s tough for the antibiotics and disinfectants to breach the biofilm barrier and kill these microorganism colonies.

Cutaneous neoplasm are a rare complication developing after a chronic bone infection. The incidence and prevalence of these cutaneous tumor/neoplasm following chronic bone infection continues to increase despite the increasing awareness to the disease process, and medical advances in early diagnosis and early treatment. Most common neoplasm after a chronic bone infection are squamous cell carcinoma and rarely sarcoma or lymphoma.1

In our study we report adenosquamous cell carcinoma arising from chronic osteomyelitis of tibia for which above knee amputation was done.

References

Basal and Squamous Cell Skin Cancer. American Cancer Society. Available from: https://www.cancer.org/cancer/types/basal-and-squamous-cell-skin-cancer.html
Celsus AC. Chapter XXVI. In: De Medicina. .
Costa JCD. Carcinomatous Changes in an Area of Chronic Ulceration, or Marjolin's Ulcer. Annals of Surgery. 1903;37(4):496–502. Available from: https://pubmed.ncbi.nlm.nih.gov/17861272/
Johnston RM, Miles JS. Sarcomas arising from chronic osteomyelitic sinuses. A report of two cases. Journal of Bone and Joint Surgery. 1973;55(1):162–168. Available from: https://journals.lww.com/jbjsjournal/abstract/1973/55010/sarcomas_arising_from_chronic_osteomyelitic.17.aspx
McGrory JE, Pritchard DJ, Unni KK, Ilstrup D, Rowland CM. Malignant lesions arising in chronic osteomyelitis. Clinical Orthopaedics and Related Research. 1999;362:181–189. Available from: https://pubmed.ncbi.nlm.nih.gov/10335297/
Gebhart M, Fabeck L, Müller C. Malignant transformation of chronic osteomyelitis and its scar tissue: report of 3 cases. Acta Orthopaedica Belgica. 1993;59(4):327–332. Available from: https://pubmed.ncbi.nlm.nih.gov/8116362/
Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s ulcer: modern analysis of an ancient problem. Plastic and Reconstructive Surgery. 2009;123(1):184–191. Available from: https://journals.lww.com/plasreconsurg/abstract/2009/01000/marjolin_s_ulcer__modern_analysis_of_an_ancient.25.aspx
Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. The Journal of Bone & Joint Surgery. 2004;86(10):2305–2318. Available from: https://journals.lww.com/jbjsjournal/abstract/2004/10000/osteomyelitis_in_long_bones.28.aspx#:~:text=Hematogenous%20osteomyelitis%20usually%20involves%20the,patients%20with%20severe%20vascular%20disease.
Gillis L, Lee S. Cancer as a sequel to war wounds. The Journal of Bone & Joint Surgery British. 1951;33(2):167–179. Available from: https://doi.org/10.1302/0301-620X.33B2.167
Altay M, Arikan M, Yildiz Y, Saglik Y. Squamous cell carcinoma arising in chronic osteomyelitis in foot and ankle. Foot & Ankle International. 2004;25(11):805–809. Available from: https://doi.org/10.1177/107110070402501109
Trent JT, Kirsner RS. Wounds and malignancy. Advances in Skin & Wound Care. 2003;16(1):31–34. Available from: https://doi.org/10.1097/00129334-200301000-00014
Zou J, Guo P, Lv N, Huang D. Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer. Molecular Medicine Reports. 2015;12(5):6399–6404. Available from: https://doi.org/10.3892/mmr.2015.4243
Khandelwal AR, Ma X, Egan P, Kaskas NM, Moore-Medlin T, Caldito G, et al. Biomarker and pathologic predictors of cutaneous squamous cell carcinoma aggressiveness. Otolaryngology–Head and Neck Surgery. 2016;155(2):281–288. Available from: https://doi.org/10.1177/0194599816641913
Laffosse JM, Bensafi H, Accadbled F, Fabié F, Tricoire JL, Puget J. Squamous-cell carcinoma and osteomyelitis: three cases and a review of the literature. Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Moteur. 2007;93(1):72–77. Available from: https://doi.org/10.1016/S0035-1040(07)90206-8
Theodorou SJ, Theodorou DJ, Bona SJ, Farooki S. Primary Squamous Cell Carcinoma: An Incidental Toe Mass. AJR Am J Roentgenol. 2005;184(3_supplement):S110 –S111. Available from: https://doi.org/10.2214/ajr.184.3_supplement.0184s110
Centofanti F, Salfi C. Squamous cell carcinoma (SCC) arising from chronic osteomyelitis: A review of 14 cases. In: International meeting on multidisciplinary approach to treatment of bone and soft tissue sarcomas. Abstract Book. (pp. 58-60) 1999.
Alami M, Mahfoud M, Bardouni AE, Berrada MS, Yaacoubi ME. Squamous cell carcinoma arising from chronic osteomyelitis. Acta Orthopaedica et Traumatologica Turcica. 2011;45(3):144–148. Available from: https://doi.org/10.3944/aott.2011.2537

Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka