Bilirubin in Diabetic Retinopathy: Too Little or Too Much?

Harish R; Shashidhar K N

doi:10.58739/jcbs/v13i2.23.11

Article

Bilirubin in Diabetic Retinopathy: Too Little or Too Much?

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Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v13i2.23.11

Year: 2023, Volume: 13, Issue: 2, Pages: 32-33

Editorial

Bilirubin in Diabetic Retinopathy: Too Little or Too Much?

Harish R^1,*, Shashidhar K N²

¹ Assistant Professor, Department of Biochemistry, Haveri Institute of Medical Sciences, Haveri, 581110, Karnataka, India
² Professor and HoD, Department of Biochemistry, Sri Devaraj Urs Medical College Constituent of Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, 563103, Karnataka, India

*Corresponding author email: [email protected]

Received Date:23 March 2023, Accepted Date:10 June 2023, Published Date:10 July 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Diabetic retinopathy (DR) is a significant diabetic complication that may result in loss of vision and blindness. The development of DR is intricate and encompasses numerous processes, such as oxidative stress. Bilirubin, a powerful antioxidant, has been proposed as a probable indicator for oxidative stress in DR. Bilirubin is a powerful antioxidant that helps to eliminate free radicals and other reactive oxygen species (ROS) in the body by being produced during the breakdown of heme. Additionally, it aids in the regulation of the expression of antioxidant genes, further bolstering its antioxidant properties. Therefore, bilirubin plays a crucial role in safeguarding cells from oxidative stress. Oxidative stress arises when there is an imbalance between ROS production and the body's ability to detoxify them. This can result in oxidative damage to cellular components like proteins, lipids, and DNA. Oxidative stress has been implicated in the development of various ailments, including Diabetic Retinopathy (DR).

Keywords: Bilirubin, Diabetic retinopathy, Oxidative stress

References

Shawki HA, Elzehery R, Shahin M, Abo-Hashem EM, Youssef MM. Evaluation of some oxidative markers in diabetes and diabetic retinopathy. Diabetol Int. 2020;12(1):108–117. Available from: https://doi.org/10.1007%2Fs13340-020-00450-w
Liu Y, Duan C, Fang D, Liu Y, Xu H, Zheng Y, et al. Protective factors for diabetic retinopathy in Type 2 diabetes mellitus patients: Long duration of no less than 10 years. Journal of Diabetes and its Complications. 2019;33(10):107383. Available from: https://doi.org/10.1016/j.jdiacomp.2019.05.014
Ding Y, Zhao J, Liu G, Li Y, Jiang J, Meng Y, et al. Total Bilirubin Predicts Severe Progression of Diabetic Retinopathy and the Possible Causal Mechanism. Journal of Diabetes Research. 2020;2020:1–7. Available from: https://doi.org/10.1155/2020/7219852
Bianco A, Tiribelli C, Bellarosa C. Translational Approach to the Protective Effect of Bilirubin in Diabetic Kidney Disease. Biomedicines. 2022;10(3):696. Available from: https://doi.org/10.3390/biomedicines10030696
Yao Q, Chen R, Ganapathy V, Kou L. Therapeutic application and construction of bilirubin incorporated nanoparticles. Journal of Controlled Release. 2020;328:407–424. Available from: https://doi.org/10.1016/j.jconrel.2020.08.054
Liu M, Wang J, He Y. The U-Shaped Association between Bilirubin and Diabetic Retinopathy Risk: A Five-Year Cohort Based on 5323 Male Diabetic Patients. J Diabetes Res. 2018;2018:4603087. Available from: https://doi.org/10.1155/2018/4603087

Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka