Journal of Clinical and Biomedical Sciences
Year: 2015, Volume: 5, Issue: 3, Pages: 114-117
Original Article
Rohin1, Mounika Deepthi I1, Frsha Nozer Taraporewalla1, Prathyusha A1, Nancy1, Bhavana1, Nusrath Fathima2, Nusrath Farees1, Ayesha Jehan1, Roya Rozati1*
1.Dept of Obestetrics & Gynaecology, Deccan College of Medical Sciences, Hyderabad, AP, India
2.Dept of Genetics, Osmania University, Hyderabad, AP, India
*Corresponding Author
E-mail : [email protected]
Background: Recurrent Pregnancy Loss (RPL) is defined as the occurrence of three (or) more clinically recognised pregnancy losses before 20 weeks of gestation. Spontaneous abortions occur in 15% of clinically recognised pregnancies in reproductive age group women. Hyper homocysteinemia has been associated with clinical vascular thrombosis and this could be the cause for early decidual and chorionic vessel damage that might result in disturbed implantation of the conceptus. Aim: To determine the plasma homocysteine levels in patients with polycystic ovarian syndrome (PCOS) having recurrent pregnancy loss (RPL) compared with women with PCOS who had uneventful pregnancies and assess the role of hyper homocysteinemia for RPL in PCOS. Materials and Methods: This is a case-control study on 20 PCOS women with RPL and 20 control PCOS women with uneventful pregnancies matched by age, marriage duration and body mass index(BMI). Plasma homocysteine levels were assessed from Feb, 2013 to Feb, 2014. Results: The mean plasma homocysteine in the cases and controls were 19.10±1.01 and 16.41±1.24 (p=0.0001). The difference in the homocysteine levels was found to be statistically significant. Conclusion: Risk of RPL in patients with PCOS is increased with hyperhomocysteinemia (p< 0.0001).
Key-words: Plasma homocysteine levels, PCOS, early recurrent pregnancy loss
Subscribe now for latest articles and news.
