Journal of Clinical and Biomedical Sciences
Year: 2016, Volume: 6, Issue: 4, Pages: 121-124
Original Article
Harsha N S1, Thimma Reddy SR2*, Shruthi M3, Ravishankar SN4, Madhuvan HS2
1. Associate Professor
2. Assistant Professor
3. Senior Resident
4. Professor, Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Karnataka, India.
*Corresponding Author
E-mail: [email protected]
Background: Infections are the commonest cause of thrombocytopenia. Hence fever associated with thrombocytopenia helps to narrow down the differential diagnosis to infectious causes, plan manage-ment and anticipate complications Aim: The objective is to identify the possible infectious causes of fever with thrombocytopenia and to study the clinical profile and complications of such patients. Materials and Methods: This is a prospective study of 100 patients admitted with fever and thrombocytopenia in a medi-cal college hospital. The clinical profile, infectious causes, outcome and laboratory features are studied. Results: Dengue (47%) was the most commonest infectious cause among the patients with fever and thrombocytopenia followed by septicaemia and malaria. Bleeding manifestations were observed in 44% of the patients. Petechial rashes or purpura were the commonest haemorrhagic manifestation (66%) and spontaneous bleeding in the rest of them (34%). Majority of those with spontaneous bleeding had plate-let count of <30000/μl. The mortality rate among the series of patients was 11% and septicaemia account-ed for 72% followed by malaria in 18%. Conclusion: Dengue is the commonest infectious disease among patients hospitalised with fever and thrombocytopenia.
Keywords: Dengue, thrombocytopenia, spontaneous bleeding, febrile illness
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