Journal of Clinical and Biomedical Sciences
Year: 2013, Volume: 3, Issue: 4, Pages: 177-181
Original Article
Jose Angel1, Kumar Sai Sailesh2, Mukkadan J.k*3
1. Department of Physiology, Little Flower Medical Research Centre, Angamaly, Kerala, India. 2.Department of Physiology, Travancore Medical College, Kollam. , India.
3. Research Director, Little Flower Medical Research Centre, Angamaly, Kerala, India.
*Corresponding Author
E mail : [email protected]
Background: Therapeutic agents like sulfonyl urea, biguanides etc are used to control blood glucose level in diabetic patients. However chronic usage of most of these agents produces adverse effects. The present study was undertaken with an objective to observe effectiveness of oral administration of Peppermint juice in alloxan induced diabetic wistar rats. Methods: Thirty adult male and female Wistar rats, weighing 150-200g, were selected for this study. Blood glucose was estimated by GOD-PAP method using diagnostic kit supplied by Agappe diagnostics, Maharashtra. Two Sample t- test, One way ANOVA are used to analyse the data. Results: The present experimental study provides further evidence that oral administration of Peppermint juice for 21 days produced a significant decrease (p <0.0010) in the blood glucose level of alloxan induced diabetic rats. Conclusion: From this study, we can conclude that the oral administration of Peppermint juice have beneficial effect on blood glucose levels. However further pharmacological and biochemical investigations will clearly elucidate the mechanism of action and helpful in projecting Peppermint juice as a therapeutic target in diabetes research.
Key words: Anti diabetic effect, Peppermint juice, Wistar rats.
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