Laron Syndrome (LS) – A Rare Case Report

Deepthi S S N S P; Karthik S; Tejasvi S; Sudha Reddy V R  lowast

doi:10.58739/jcbs/v15i2.24.41

Article

Laron Syndrome (LS) – A Rare Case Report

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Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v15i2.24.41

Year: 2025, Volume: 15, Issue: 2, Pages: 136-138

Case Report

Laron Syndrome (LS) – A Rare Case Report

Deepthi S S N S P¹, Karthik S², Tejasvi S³, Sudha Reddy V R^4∗

¹Junior Resident, Department of Paediatrics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India
²Assistant Professor, Department of Paediatrics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India
³Paediatric Endocrinologist, Department of Paediatrics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India
⁴Professor & Head, Department of Paediatrics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, 563103, Karnataka, India

*Corresponding Author
Email: [email protected]

Received Date:30 May 2024, Accepted Date:20 August 2024, Published Date:13 July 2025

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Laron syndrome or growth hormone insensitivity (GHI) is a rare genetic disease inherited in an autosomal recessive manner. A 6 ½ year-old-female child was bought to Paediatric OPD for short stature which was noticed by parents since 3 years of age. Child is first born to second degree consanguineous married couple with no significant birth history, and family history of short stature. Child presented with weight of 10 kg (<3rd centile), height of 90 cm (<3rd centile). Growth Hormone (GH) stimulation test done with tablet Clonidine revealed high GH levels suggestive of partial/total resistance. IGF-1 generation test was done which also showed low IGF-1 levels supporting the diagnosis of GH insensitivity or Laron Syndrome. A high index of clinical suspicion is required for the diagnosis of LS or GH insensitivity in a child with severe short stature having high serum GH levels but low levels of IGF-1 and IGF- BP3.

Keywords: Laron Syndrome, Growth Hormone, Insulin like growth factor1(IGF1)

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Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka