JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES

Abstract

Background: Maturity onset diabetes of the young (MODY) is a heterogeneous familial diabetes mellitus characterized by early age of onset, autosomal dominant inheritance and primary defects of insulin secretion. Studies have shown increased oxidative stress levels in diabetes patients which has the potential to be used as biomarkers for detection and management. This study was undertaken on patients presenting with MODY in a medical college hospital to asses the oxidative stress levels. Materials and Methods: Serum levels of protein carbonyls, malondialdehyde (MDA), catalase and superoxide dismutase (SOD) were esti-mated in 31 patients categorized as MODY. The serum levels of the oxidants and antioxidants were also measured in age and sex matched controls. Mann-Whitney test was used to assess the statistical significance of differences in the serum assay values of the oxidative stress parameters between the groups. Results: The catalase and SOD levels were 44.4 ± 11.8 and 47.3 ± 16.8 U/L respectively and protein carbonyls and MDA were 33.2 ± 8.5 and 0.84 ± 0.29 μ mol/L respectively. Conclusions: Hence it is concluded that antioxi-dants levels are increased and the oxidants levels are decreased in patients with MODY suggesting their possible role as biomarkers.

Keywords: MODY, oxidants, antioxidants, biomarkers