Journal of Clinical and Biomedical Sciences
Year: 2018, Volume: 8, Issue: 1, Pages: 10-13
Original Article
Deena Mendez1, Prasad SR2, Kutty AVM3*
1. Assistant Professor, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar
2. Professor and PG Director, Department of Microbiology, Sri Devaraj Urs Medical College, Kolar
3. Professor, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.
*Corresponding Author
E-mail : [email protected]
Human Neutrophil Elastase (HNE) is released from neutrophils when foreign substances are encoun-tered. Elastase is also released by invasive pathogenic microorganisms and is an important virulence factor. Serine protease inhibitors counter the elastase released in excess to prevent the damage of tissues. Aim: The aim of this study was to assess the specificity of the endogenous protease inhibitors α1 Anti trypsin( α1AT) and α2 Macroglobulin( α2MG) on Human Neutrophil Elastase and elastase released by Pseudomonas aeruginosa. Result: It was observed that Pseudomonal elastase exhibited resistance to inhibition in com-parison to Human Neutrophil Elastase particularly by α1 Anti trypsin. However, the inhibition patterns of these enzymes were more or less similar in both the cases by α2 Macroglobulin. Conclusion; α1AT is a less potent inhibitor of Pseudonomas aeruginosa elastase and might require exogenous inhibitory substances to control the damaging effects of this enzyme.
Keywords: α1 Anti trypsin, α2 Macroglobulin, Human Neutrophil Elastase, Pseudomonas aeruginosa
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