Formulation and Characterization of the Esomeprazole Microsponge Loaded in-situ Gel

Joshi Vineet  lowast; Raja Md  Hussain; Dobhal Kiran

doi:10.58739/jcbs/v15i3.25.77

Article

Formulation and Characterization of the Esomeprazole Microsponge Loaded in-situ Gel

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Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v15i3.25.77

Year: 2025, Volume: 15, Issue: 3, Pages: 204-210

Original Article

Formulation and Characterization of the Esomeprazole Microsponge Loaded in-situ Gel

Joshi Vineet^1∗, Raja Md. Hussain¹, Dobhal Kiran²

¹College of Pharmacy, Shivalik Campus Dehradun, 248197, Uttarakhand, India
²Assistant professor, College of Pharmacy, Shivalik Campus, Dehradun, 248197, Uttarakhand, India

*Corresponding Author
Email: [email protected]

Received Date:25 March 2025, Accepted Date:15 April 2025, Published Date:26 September 2025

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: This study investigates establishing a novel therapeutic approach to treating peptic ulcers that uses an in-situ gel microsponge incorporating esomeprazole. Microsponges carrying esomeprazole magnesium, ethyl cellulose, and Eudragit RS-100 were developed via a quasi-emulsion solvent diffusion technique. Methods: Five formulations were developed and analyzed for entrapment efficiency, drug content, yield, and particle size. Results: From all the five formulations, the F3 formulation showed the maximum results in terms of high drug content (85.24%), entrapment efficacy (85.67 %), particle size (8.36±0.43 µm), and production yield (87.35%). Then the microsponges were incorporated with the Poloxamer 188 to form in-situ gel. The formulation (F3) demonstrated appropriate viscosity (38cps), gelling time (11.95±0.56 sec), and gelling capacity (++). The in-vitro drug release profile revealed that formulation F3 exhibited an extended drug release rate (92.18%). Stability studies indicated minimal changes in particle size (8.36±0.43) and entrapment efficiency (85.67) over three months. Conclusion: This innovative Esomeprazole-loaded microsponge in- situ gel formulation is promising to enhance drug delivery, prolong drug release, and improve patient compliance in peptic ulcer therapy.

Keywords: Microsponge, Esomeprazole, Gastric, Peptic Ulcer, In-situ gel

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