JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES

Abstract

Background and Rationale: Understanding neuroplasticity—the brain’s ability to reorganize itself through the formation of new neural connections—offers profound implications for cognitive development, particularly in children. Despite substantial theoretical and clinical evidence, limited experimental studies have investigated the efficacy of neuroplasticity-based strategies in educational settings through a randomized controlled trial (RCT) framework. Objective: This study aimed to evaluate the impact of neuroplasticity-driven interventions on cognitive functions, neural connectivity, and academic performance. It also explored the feasibility, scalability, and long-term effects of such strategies in mainstream educational contexts. Methods: A six-month RCT was conducted with 100 postgraduate students (aged 22–25 years) at Arizona State University. Participants were randomized into experimental and control groups. The experimental group engaged in neuroplasticity-based activities targeting memory, attention, and problem-solving skills, while the control group followed standard academic routines. Pre- and post-intervention assessments included cognitive tests (WISC-V, CPT 3, BRIEF-2) and neuroimaging techniques (fMRI). A follow-up evaluation was conducted three months post-intervention. Results: Significant improvements were observed in the experimental group across cognitive domains, including a 56.12% enhancement in spatial processing and a 63.87% increase in attention efficiency. Neuroimaging revealed marked improvements in functional connectivity (+46.89% to +50.24%) within critical brain networks, such as the Default Mode and Cognitive Control Networks. These gains were sustained at follow-up, indicating durable neuroplastic benefits. Conclusion: This study demonstrates that structured neuroplasticity-based interventions can significantly enhance cognitive functions, optimize executive processes, and foster neural plasticity. The findings highlight the potential of these strategies to revolutionize educational practices and cognitive training methodologies. Future research should extend these interventions to diverse populations and explore their applicability in broader educational and clinical settings.

Keywords: Neuroplasticity, Cognitive Development, Learning Strategies, Neural Connectivity, Cognitive Performance