Journal of Clinical and Biomedical Sciences
Year: 2014, Volume: 4, Issue: 1, Pages: 235-239
Short communications/brief reports
Shilpashree M K1*, Ravi B V2, Vedavathi3
1. Department of Biochemistry, BGS - Global Institute of Medical Sciences, Bangalore , Karnataka. India.
2. Department of Biochemistry, Kempegowda Institute of Medical Sciences , Bangalore , Karnataka. India.
3. Department of General Medicine, Kempegowda Institute of Medical Sciences , Bangalore , Karnataka. India
*Corresponding Author
E mail : [email protected]
Background: Hypothyroidism has been found to be a predictor of cardiovascular disease. Among various reasons, dyslipidemia and elevated lipoprotein (a) is a significant cause. This study was conducted to determine the serum lipid disturbances and the significance of lipoprotein (a) in hypothyroid patients. Methods: The study subjects were 40 hypothyroid patients along with 30 normal persons matched for age and gender as controls. All were tested for serum lipoprotein (a), thyroid and lipid profile. The data was analysed using Mann-Whitney U test. Results: Majority were females (89%) in the age group of 41-50 years. Cases had significantly higher TC, LDL, VLDL, Triglycerides, LDL: HDL ratio, TC: HDL and Reduded HDL ratio compared to controls. The number of cases with Lp (a) of> 30 mg/dl is found to be significantly higher than that of controls.Conclusion: The study suggests that hypothyroidism contributes to the development of atherosclerosis by making the lipid profile more atherogenic.
Key words: Hypothyroidism, Lipoprotein (a), atherosclerosis.
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