JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES

Abstract

Syphilis prevalence varies by region. It remains prevalent in many developing countries. New cases of primary and secondary syphilis are more in the age group of 25 – 29 years.[1] The etiological agent Treponema pallidum cannot be cultivated in vitro. The organism is so nar-row; the volume of protoplasm so small that it is extremely difficult to see by direct illumina-tion and ordinary staining methods. Silver im-pregnation technique and immune fluorescent staining techniques have proved of value.[2] In clinical work, dark ground illumination is the usual method employed. Serological testing is considered the standard methods for diagnosis for all stages of syphilis.[3] Diagnosis of syphilis is made with certainty by finding Treponema pallidum from mucocutaneous lesions and lymph node aspirate.