Journal of Clinical and Biomedical Sciences
DOI: 10.58739/jcbs/v16i1.25.167
Year: 2026, Volume: 16, Issue: 1, Pages: 54-62
Original Article
Prashant Pawar1*, Sahil Sabale2, Sanket Bhosale2, Snehal Gojare1, Shivraj Mane3
1Assistant Professor, Department of Pharmacology, PES’s Modern College of Pharmacy, Sec. No. 21, Yamunanagar, Nigdi, Pune 411044, Maharashtra, India.
2Research Scholar, PES’s Modern College of Pharmacy, Sec. No. 21, Yamunanagar, Nigdi, Pune 411044, Maharashtra, India.
3Assistant Professor, Department of Pharmaceutics, PES’s Modern College of Pharmacy, Sec. No. 21, Yamunanagar, Nigdi, Pune 411044, Maharashtra, India
*Corresponding Author
Email: [email protected]
Received Date:05 April 2025, Accepted Date:30 December 2025, Published Date:20 April 2026
Hepatocellular carcinoma (HCC), one of the most prevalent forms of liver cancer, remains a significant global health challenge due to its aggressive nature and limited treatment options. This study explores the potential anticancer properties of crude extracts derived from Moringa oleifera a plant known for its rich phytochemical profile and medicinal properties on HepG2 liver cancer cells. The investigation employed in vitro assays, including MTT and cell migration assays, to evaluate cytotoxic and anti-metastatic effects. The MTT assay revealed a dose-dependent reduction in cell viability, with an IC₅₀ value of 464 µg/mL, indicating cytotoxic potential of the crude extract. Additionally, the cell migration assay demonstrated that Moringa oleifera significantly inhibited cell migration, a key process in cancer metastasis. These findings suggest that crude Moringa oleifera extract exhibits promising anticancer activity against hepatocellular carcinoma through inhibition of cell proliferation and migration, supporting its potential use as a natural therapeutic agent. Further studies involving purified constituents and in vivo models are warranted to validate and optimize its efficacy.
Keywords: Moringa oleifera, Hepatocellular carcinoma, HepG2 cells, MTT assay, Cell migration
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Published By Sri Devaraj Urs Academy of Higher Education, Kolar, Karnataka
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