Fatal Intracranial Haemorrhage due to HPA-2b Incompatible Foetal Alloimmune Thrombocytopenia and Antenatal Management of Subsequent Pregnancy

Arun Francis; Sarat Chandra G; Aruna Rajendran

doi:10.58739/jcbs/v06i2.1

Article

Fatal Intracranial Haemorrhage due to HPA-2b Incompatible Foetal Alloimmune Thrombocytopenia and Antenatal Management of Subsequent Pregnancy

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Journal of Clinical and Biomedical Sciences

DOI: 10.58739/jcbs/v06i2.1

Year: 2016, Volume: 6, Issue: 2, Pages: 64-67

Case Report

Fatal Intracranial Haemorrhage due to HPA-2b Incompatible Foetal Alloimmune Thrombocytopenia and Antenatal Management of Subsequent Pregnancy

Arun Francis¹, Sarat Chandra G¹, Aruna Rajendran^2*

1. Department of Neonatology,
2. Division of Paediatric Haematology Oncology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

*Corresponding Author
E-mail: [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Intracranial hemorrhage as a presenting feature of neonatal Alloimmune thrombocytopenia is an uncommon manifestation and is a predictor of recurrent risk in future pregnancy. The index child had an uncommon Human Platelet Antigen (HPA-2b) causing feto-maternal incompatibility leading to in-utero intracranial hemorrhage. The rarity of this antigen in the population posed a challenge in establishing the diagnosis. With the aid of HPA genotyping the father was found to be heterozygous for this antigen which led to proceed with the antenatal diagnosis of the condition in the subsequent pregnancy.

Keywords: Neonatal Alloimmune Thrombocytopenia, NAIT, Human Platelet Antigen, Antenatal Diagnosis, Intracranial Hemorrhage