JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES

Abstract

Objectives:This study was conducted to know the association between homocysteine levels in acute myocardial infarction patients and to compare with the first degree relative of the patients and controls attending R. L. Jalappa Hospital, affiliated to Sri Devaraj Urs Medical College, Kolar. Methodology: The study included 50 acute myocardial infarction patients, 50 first degree relative of the patients and 50 healthy controls. Serum homocysteine levels were measured in all the groups and the levels were studied and compared among the groups. Serum homocysteine was assayed by chemiluminescence microparticle immunoassay. Results: The mean Homocysteine levels in the patient group were 25.2±14.7µmol/l and in the first degree relative of the patient, it was 14.1±3.4 µmol/l and in controls was 11.7±2.9µ mol/l .The levels were higher in patients when compared to the other two groups. Homocysteine levels were elevated in 64% of the patients, and 32% of the first degree relative and 18% of controls. Hyperhomocysteinemia without any risk factors was present in 18% of the patients. Conclustion: Homocysteine emerged as an independent risk factor in acute myocardial infarction. Therefore it should be evaluated in all patients with acute myocardial Infarction. Key Words: Homocysteine, Acute myocardial infarction